Lab, Data, Value
Stemick GmbH is your dedicated partner for pharmaceutical and life-science R&D. We deliver specialized research services leveraging our expertise in assay development. Our core capabilities, including tailored cell-based assays, radiometric assays, and cutting-edge analysis of extrinsic/intrinsic oxidative stress and ferroptosis, provide definitive answers for your critical toxicology and pharmacology questions.
stemick
We are a start-up company based in Constance, Germany, that provides research and development services for pharmaceutical and life science businesses. Our key competencies include tailored cell-based assays and radiometric assays in the field of toxicology and pharmacology.
We believe that close collaboration with clients, partners and experts is most fruitful and efficient to deliver our clients best on-target solutions.
Services and Products
Stemick is offering cell-based and cell-free assays based on fluorescent and radiometric readouts in the field of toxicology and pharmacology. We identify and implement tailored solutions for clients who wish to investigate the pharmacology or test for potential toxicities of their compounds in the nervous or other organ systems.
Radiometric assays
- Receptor binding assays using radio-labeled drug candidates (cell-based or cell-free)
- Ligand-binding assay using radiolabeled natural ligand (cell-based or cell-free)
- Kinase activity assays using labeled ATP or other enzyme activity assays
- Transporter assays using labeled substrates, cell-based
Cell-based toxicology
- Variety of mammalian cell culture models (HepG2, HEK293, U937, J77A4.1, etc.)
- Human neuronal cell model derived from embryonic stem cells (LUHMES)
- Co-culture models (e.g. neurons and astrocytes)
- Resazurin assay, mitochondrial activity
- Lactate dehydrogenase (LDH) assay, membrane integrity
- Adenosine triphosphate (ATP) assay, metabolic activity
- Glutathione (GSH) assay, metabolism and oxidative stress
Human neuronal cell system
Stemick develops together with academic partners screening-compatible test systems based on human neurons (LUHMES cells) to discover new drugs for the treatment of neurodegenerative diseases such as Parkinson‘s.
- Cellular in vitro model for precursor or postmitotic neurons with a dopaminergic phenotype
- Co-culture models (e.g. neurons and astrocytes)
- Proliferation and differentiation of LUHMES cells
- Cellular mechanisms in neurodegenerative, especially Parkinson’s disease
- Investigation of protective substances (potential new drugs)
- Testing of potentially damaging compounds (insecticides, flame retardants, drugs, etc.)
Automation and scaling
Stemick works on automation solutions together with partners. Our activities are focused on compound management, integration and testing of automated subtasks including liquid handling and cell culture.
statistical data analysis and experimental design
Stemick offers services related to statistical data analysis and experimental design. Deliverables that can add value for the client’s development process include statistical analysis plans, sample size calculations or statistical data analyses for research reports or publications.
contract research
assay development
data analysis
consulting
collaborations and partners
stemick works with academic and commercial partners to constantly improve existing and develop new services. We believe that collaboration is most fruitful and efficient when it comes to adapting novel methodologies in dynamic areas of research. In addition, stemick is continuously looking for partners to develop new services and products collaboratively.