lab, data, value
stemick is looking for partners to develop services and products collaboratively.
stemick
stemick is a start-up company that provides research and development services for pharmaceutical and life science businesses. Key competencies of stemick are tailored cell-based assays in the field of toxicology and pharmacology.
We believe that close collaboration with clients, partners and experts is most fruitful and efficient to deliver our clients best on-target solutions.
services and products
stemick is offering cell-based assays in the field of toxicology and pharmacology. Our main goal is the identification and implementation of tailored solutions that efficiently solve specific questions of our clients.
Clients who need to test their compounds for potential toxicities in the nervous or other organ systems would come to stemick and decide about the approaches. When working with stemick you will benefit by receive results adding most value for your investment of time and money. stemick achieves this by identifying the right model and the right assay,
which can be simple off the shelf solutions, an available specialized assay or a tailored novel method that needs to be established.
We are constantly working on the establishment of new assays and look for related collaborations to keep up with the ever-growing diversities and complexities of cell-based toxicological and pharmacological methods. In particular, stem-cell-based or co-culture experimental systems become more attractive and more widely used. The establishment of such systems so that they can reliably and reproducibly used in screening approaches is challenging and time consuming.
pharmacological and toxicological tests in human neuronal cell system
In high-throughput screening (HTS), libraries containing hundreds of thousands of compounds are tested in biochemical or cell-based assays. Together with academic partners stemick develops screening-compatible test systems based on human neurons to discover new drugs for the treatment of neurodegenerative diseases such as Parkinson‘s. The starting point are the LUHMES cells, an established test system for human neurons that enables controlled, reproducible differentiation into dopaminergic neurons and is primarily used in toxicology. For industrial use in pharmacological drug research, cell systems are adapted and optimized for smaller test volumes and higher throughputs. The added value consists of providing a human central nervous cell system that reproducibly exhibits the intended functional properties of the neurons and that can be used in screening approaches in pharmaceutical research.
toxicology
Stemick offers testing of compounds in medium throughput scale for potential tissue-relevant toxicity (cytotoxicity). Applying cell-based toxicity tests earlier in the development process using a sensitive analysis approach supports candidate selection and qualification. Together with partners stemick adapts and develops solutions for comprehensive in vitro toxicology and safety pharmacology to assess drug safety profiles.
automation
Besides contracted research, Stemick works on automation solutions together with partners. Our activities are focused on compound management, integration and testing of automated subtasks including liquid handling and cell culture.
statistical data analysis and experimental design
Stemick offers services related to statistical data analysis and experimental design. Deliverables that can add value for the client’s development process include statistical analysis plans, sample size calculations or statistical data analyses for research reports or publications.
contract research
assay development
data analysis
consulting
collaborations and partners
stemick works with academic and commercial partners to constantly improve existing and develop new services. We believe that collaboration is most fruitful and efficient when it comes to adapting novel methodologies in dynamic areas of research. In addition, stemick is continuously looking for partners to develop new services and products collaboratively.